SREBF1

Across TCGA patient cohorts, SREBF1 mutation is significantly associated with the RNA expression of many other genes, with 3,674 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SREBF1-associated genes across cancer lineages are MIR4304, BPY2DP, and RPSAP38. Each is linked with SREBF1 in more than 2 cancer types. Because this analysis shows association rather than direction, both SREBF1-to-partner and partner-to-SREBF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR4304 grouped by SREBF1-low versus SREBF1-high in LIHC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SREBF1→partner) and Y-score (partner→SREBF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIHC	MIR4304 →	+0.275	+4.902	<.001	.003	3	3
COAD	BPY2DP →	+0.218	+5.994	<.001	<.001	3	2
COAD	RPSAP38 →	+0.164	+3.184	<.001	.006	3	2
CESC	MRGPRX6P →	+0.024	+5.263	<.001	.001	3	2
BRCA	TTTY8B →	+0.044	+8.055	<.001	.007	3	2
LUAD	VENTXP4 →	+0.061	+4.631	<.001	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,674 associations by consensus.

MIR4304 by SREBF1 expression — LIHC

Explore this box plot interactively →