SREBF1

Across TCGA pan-cancer cohorts, SREBF1 RNA is linked to patient survival in 28 of 34 cancer types, making it the most broadly survival-associated SREBF1 data layer compared with 8 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in mesothelioma (MESO), where higher SREBF1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated SREBF1 expression acts as an unfavorable survival marker, although some lineages such as SCLC and UCEC show a favorable association.

MESO, BLCA, and UVM are the cancer types where SREBF1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	DFS	Median	IV	0.185	0.473	.004	84	view →
BLCA	OS	Quartile	III,IV	0.303	0.625	.005	43	view →
UVM	DFS	Tertile	II,III,IV	0.497	0.855	.005	33	view →
SCLC	OS	Quartile	III,IV	0.647	0.288	.007	32	view →
UCEC	DFS	Tertile	All	0.878	0.788	.006	32	view →
BRCA	DFS	Median	III,IV	0.936	0.821	<.001	31	view →
LAML	DFS	Tertile	All	0.239	0.640	.006	30	view →
LIHC	OS	Tertile	II,III,IV	0.328	0.631	<.001	30	view →
HNSC	DFS	Tertile	All	0.785	0.630	.001	27	view →
OV	OS	Quartile	III,IV	0.256	0.369	.012	24	view →
COAD	DFS	Quartile	All	0.352	0.728	.002	18	view →
KIRC	DFS	Tertile	IV	0.355	0.661	.008	16	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 28 lineages.

SREBF1–MESO (DFS)

Open the MESO breakdown →