SQLE

Across TCGA patient cohorts, SQLE mutation is significantly associated with the RNA expression of many other genes, with 1,963 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SQLE-associated genes across cancer lineages are RNU6-1082P, RNU6-937P, and CICP28. Each is linked with SQLE in more than 1 cancer types. Because this analysis shows association rather than direction, both SQLE-to-partner and partner-to-SQLE results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-1082P grouped by SQLE-low versus SQLE-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SQLE→partner) and Y-score (partner→SQLE) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNU6-1082P →	+0.205	+2.551	<.001	.006	3	2
SKCM	RNU6-937P →	+0.642	+4.603	<.001	.001	3	2
SKCM	CICP28 →	+0.024	+4.302	<.001	.002	3	2
SKCM	MIR510 →	+0.346	+6.643	<.001	<.001	3	2
COAD	RPSAP38 →	+0.175	+4.354	.007	.007	3	2
UCEC	RNA5SP415 →	+0.587	+2.266	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,963 associations by consensus.

RNU6-1082P by SQLE expression — UCEC

Explore this box plot interactively →