SQLE

Across TCGA pan-cancer cohorts, SQLE RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated SQLE data layer compared with 3 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher SQLE RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated SQLE expression acts as an unfavorable survival marker, although some lineages such as UCS and GBM show a favorable association.

UVM, HNSC, and KIRP are the cancer types where SQLE RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Median	All	0.397	0.767	<.001	145	view →
HNSC	DFS	Median	All	0.537	0.667	<.001	141	view →
KIRP	OS	Tertile	All	0.637	0.823	<.001	134	view →
LIHC	OS	Quartile	All	0.638	0.843	<.001	94	view →
BLCA	DFS	Quartile	All	0.415	0.583	<.001	81	view →
CESC	OS	Median	III,IV	0.242	0.731	.002	72	view →
MESO	OS	Tertile	All	0.260	0.573	<.001	64	view →
THCA	OS	Median	All	0.895	0.975	.003	57	view →
LUAD	OS	Median	All	0.617	0.744	<.001	53	view →
ACC	DFS	Tertile	All	0.153	0.672	.001	52	view →
SARC	OS	Median	All	0.382	0.628	<.001	47	view →
KIRC	DFS	Quartile	II,III,IV	0.348	0.562	.006	30	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

SQLE–UVM (DFS)

Open the UVM breakdown →