Across TCGA patient cohorts, SPTSSB mutation is significantly associated with the RNA expression of many other genes, with 1,525 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPTSSB-associated genes across cancer lineages are RNU6-1228P, YTHDF3-AS1, and GAS2L2. Each is linked with SPTSSB in more than 1 cancer types. Because this analysis shows association rather than direction, both SPTSSB-to-partner and partner-to-SPTSSB results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPTSSB→partner) and Y-score (partner→SPTSSB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNU6-1228P →	+0.134	+3.634	.005	.001	3	2
UCEC	YTHDF3-AS1 →	+0.557	+3.609	.003	.001	3	1
UCEC	GAS2L2 →	-1.183	-3.448	.005	.005	3	1
UCEC	IGHV3OR16-8 →	+0.556	+2.409	.008	.001	3	1
UCEC	BNIP3P4 →	+0.053	+2.577	<.001	.006	3	1
UCEC	ZNHIT3 →	+0.504	+4.191	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,525 associations by consensus.

Exploration

SPTSSB survival (RNA) · tumor vs normal (RNA) · all SPTSSB data types