Across TCGA pan-cancer cohorts, SPTSSB RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated SPTSSB data layer compared with 2 for mutation status.
The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher SPTSSB RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated SPTSSB expression acts as an unfavorable survival marker, although some lineages such as SCLC and HNSC show a favorable association.
KIRC, KIRP, and SCLC are the cancer types where SPTSSB RNA most reproducibly stratifies survival.
RNA survival associations by lineage
Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.