SPTBN5

Across TCGA patient cohorts, SPTBN5 mutation is significantly associated with the RNA expression of many other genes, with 7,003 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPTBN5-associated genes across cancer lineages are ZNF695, GRPEL1, and EIF2S1. Each is linked with SPTBN5 in more than 4 cancer types. Because this analysis shows association rather than direction, both SPTBN5-to-partner and partner-to-SPTBN5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZNF695 grouped by SPTBN5-low versus SPTBN5-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPTBN5→partner) and Y-score (partner→SPTBN5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	ZNF695 →	+0.703	+2.614	.001	.005	3	5
UCEC	GRPEL1 →	+0.419	+1.925	<.001	<.001	3	5
UCEC	EIF2S1 →	+0.514	+1.617	<.001	<.001	3	5
STAD	IER3IP1 →	+0.541	+3.476	<.001	.002	3	5
UCEC	OIP5 →	+0.805	+2.072	<.001	<.001	3	5
UCEC	KNSTRN →	+0.519	+1.983	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,003 associations by consensus.

ZNF695 by SPTBN5 expression — CESC

Explore this box plot interactively →