SPTBN5

Across TCGA pan-cancer cohorts, SPTBN5 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of SPTBN5’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where SPTBN5 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types SPTBN5 is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

COAD, KICH, and READ are the cancer types where SPTBN5 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SPTBN5 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	All	+1.054	<.001	11	view →
KICH	Male	All	−0.808	<.001	9	view →
READ	All	III,IV	+0.515	.004	4	view →
CHOL	All	All	+1.686	<.001	3	view →
LUAD	Female	All	+0.363	<.001	3	view →
THCA	Male	III,IV	−0.581	.015	2	view →
UCEC	All	All	+0.526	<.001	2	view →
LUSC	All	All	+0.323	.018	2	view →
PRAD	All	All	−0.267	.004	2	view →
BRCA	Female	All	−0.248	.018	2	view →
STAD	All	IV	+0.250	.032	1	view →
KIRC	Male	II,III,IV	−0.152	.039	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

SPTBN5–COAD

Open the COAD breakdown →