SPTBN5

Across TCGA pan-cancer cohorts, SPTBN5 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated SPTBN5 data layer compared with 10 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher SPTBN5 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated SPTBN5 expression acts as an unfavorable survival marker, although some lineages such as HNSC and LUAD show a favorable association.

HNSC, ACC, and LGG are the cancer types where SPTBN5 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Tertile	II,III,IV	0.739	0.620	.011	70	view →
ACC	DFS	Quartile	All	0.237	0.678	<.001	69	view →
LGG	DFS	Median	All	0.284	0.472	<.001	54	view →
LUAD	OS	Median	II,III,IV	0.665	0.389	<.001	51	view →
KIRC	DFS	Median	II,III,IV	0.377	0.657	<.001	50	view →
STAD	OS	Quartile	III,IV	0.921	0.228	<.001	40	view →
ESCA	OS	Quartile	III,IV	0.746	0.309	.002	20	view →
CHOL	DFS	Median	All	0.765	0.117	<.001	18	view →
PRAD	DFS	Tertile	All	0.898	0.967	.001	18	view →
COAD	DFS	Quartile	All	0.691	0.879	.008	13	view →
UCS	DFS	Tertile	III,IV	0.334	0.100	.028	12	view →
BRCA	OS	Quartile	III,IV	0.893	0.718	.004	11	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

SPTBN5–HNSC (DFS)

Open the HNSC breakdown →