SPTBN5

Across TCGA patient cohorts, SPTBN5 mutation is significantly associated with the total protein of many other genes, with 72 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPTBN5-associated genes across cancer lineages are 4E-BP1, Cyclin-E1, and ASNS. Each is linked with SPTBN5 in more than 3 cancer types. Because this analysis shows association rather than direction, both SPTBN5-to-partner and partner-to-SPTBN5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1 grouped by SPTBN5-low versus SPTBN5-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPTBN5→partner) and Y-score (partner→SPTBN5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	4E-BP1 →	+0.360	+3.700	.003	.001	3	4
BLCA	Cyclin-E1 →	+0.353	+3.169	.023	.018	3	4
UCEC	ASNS →	+0.232	+1.000	.007	.029	3	4
UCEC	ATM →	-0.474	-2.365	<.001	<.001	3	4
COAD	GAPDH →	+0.596	+2.230	.002	.006	3	3
COAD	INPP4B →	-0.430	-2.213	.002	.010	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 72 associations by consensus.

4E-BP1 by SPTBN5 expression — STAD

Explore this box plot interactively →