SPTBN5

Across TCGA cell cohorts, SPTBN5 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,812 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible SPTBN5-associated GO terms across cancer lineages are Negative regulation of syncytium formation by plasma membrane fusion, Negative regulation of myoblast fusion, and Regulation of RNA splicing. Each is linked with SPTBN5 in more than 10 cancer types. Because this analysis shows association rather than direction, both SPTBN5-to-partner and partner-to-SPTBN5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of syncytium formation by plasma membrane fusion grouped by SPTBN5-low versus SPTBN5-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SPTBN5→partner) and Y-score (partner→SPTBN5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Negative regulation of syncytium formation by plasma membrane fusion →	+0.085	+0.404	<.001	<.001	3	11
UPPER_AERODIGESTIVE_TRACT	Negative regulation of myoblast fusion →	+0.087	+0.375	<.001	.001	3	10
SOFT_TISSUE	Regulation of RNA splicing →	+0.066	+0.439	<.001	.005	3	10
PANCREAS	Negative regulation of RNA splicing →	+0.083	+0.523	.001	.006	3	10
UPPER_AERODIGESTIVE_TRACT	Negative regulation of mRNA splicing, via spliceosome →	+0.092	+0.392	<.001	<.001	3	10
UPPER_AERODIGESTIVE_TRACT	Negative regulation of mRNA processing →	+0.089	+0.376	<.001	.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,812 associations by consensus.

Negative regulation of syncytium formation by plasma membrane fusion by SPTBN5 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →