SPTBN5

Across TCGA cell cohorts, SPTBN5 mutation is significantly associated with the RNA expression of many other genes, with 1,407 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SPTBN5-associated genes across cancer lineages are MAF1, SEPSECS, and TAF4B. Each is linked with SPTBN5 in more than 3 cancer types. Because this analysis shows association rather than direction, both SPTBN5-to-partner and partner-to-SPTBN5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MAF1 grouped by SPTBN5-low versus SPTBN5-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPTBN5→partner) and Y-score (partner→SPTBN5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	MAF1 →	-0.471	-2.718	<.001	<.001	3	4
LARGE_INTESTINE	SEPSECS →	+0.592	+1.807	<.001	.005	3	3
LARGE_INTESTINE	TAF4B →	+0.591	+2.459	.002	.003	3	3
LARGE_INTESTINE	ZFP90 →	+0.740	+3.584	<.001	<.001	3	3
BLOOD_Leukemia	NR2F6 →	-0.537	-3.400	<.001	.001	3	3
BLOOD_Leukemia	PPP1R16A →	-0.727	-3.400	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,407 associations by consensus.

MAF1 by SPTBN5 expression — BLOOD_Leukemia

Explore this box plot interactively →