SPTBN5

Across TCGA cell cohorts, SPTBN5 mutation is significantly associated with the mutation status of many other genes, with 5,143 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SPTBN5-associated genes across cancer lineages are DNAJC13, TG, and FLNB. Each is linked with SPTBN5 in more than 5 cancer types. Because this analysis shows association rather than direction, both SPTBN5-to-partner and partner-to-SPTBN5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DNAJC13 grouped by SPTBN5-low versus SPTBN5-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPTBN5→partner) and Y-score (partner→SPTBN5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	DNAJC13 →	+3.281	+2.057	<.001	<.001	1	6
CNS	TG →	+2.370	+2.512	.004	.004	1	6
LARGE_INTESTINE	FLNB →	+1.910	+1.830	<.001	<.001	1	6
PANCREAS	CHD7 →	+2.777	+3.491	.001	.001	1	5
SKIN	MUC2 →	+2.797	+3.062	<.001	<.001	1	5
BLOOD_Leukemia	PCDH15 →	+1.374	+1.327	.008	.008	1	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,143 associations by consensus.

DNAJC13 by SPTBN5 expression — BLOOD_Leukemia

Explore this box plot interactively →