SPTB

Across TCGA patient cohorts, SPTB protein abundance is significantly associated with the RNA expression of many other genes, with 6,447 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPTB-associated genes across cancer lineages are HBA1, HBB, and ATF3. Each is linked with SPTB in more than 9 cancer types. Because this analysis shows association rather than direction, both SPTB-to-partner and partner-to-SPTB results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SPTB versus HBA1 in GBM, with a Pearson correlation of 0.74.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPTB→partner) and Y-score (partner→SPTB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	HBA1 →	+1.861	+0.976	<.001	<.001	3	10
PDAC	HBB →	+2.555	+0.902	<.001	<.001	3	9
OV	ATF3 →	+1.452	+0.751	.006	.001	3	8
OV	FOS →	+1.666	+0.949	<.001	<.001	3	8
PDAC	HBA2 →	+2.329	+0.932	<.001	<.001	3	8
PDAC	PPBP →	+1.400	+0.755	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,447 associations by consensus.

SPTB vs HBA1 — GBM

Explore this scatter interactively →