SPTB

Across TCGA pan-cancer cohorts, SPTB RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of SPTB’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where SPTB RNA is repressed in tumor relative to normal tissue. In most cancer types SPTB is over-expressed in tumor, although a few such as KIRC and KICH show the opposite, repressed pattern.

KIRC, LUAD, and KICH are the cancer types where SPTB tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SPTB RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	All	−1.221	<.001	12	view →
LUAD	Male	II,III,IV	+1.896	<.001	11	view →
KICH	Male	II,III,IV	−1.510	<.001	11	view →
KIRP	Male	All	−1.360	<.001	11	view →
BLCA	All	All	+0.350	<.001	8	view →
BRCA	All	All	−0.547	<.001	6	view →
LIHC	All	All	+0.260	<.001	6	view →
STAD	Male	II,III,IV	+0.287	.006	4	view →
CHOL	All	All	+0.812	.003	3	view →
HNSC	Male	All	−1.092	.039	2	view →
READ	Female	All	−0.266	.022	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

SPTB–KIRC

Open the KIRC breakdown →