SPTB

Across TCGA pan-cancer cohorts, SPTB RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated SPTB data layer compared with 10 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher SPTB RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated SPTB expression acts as an unfavorable survival marker, although some lineages such as PAAD and ACC show a favorable association.

UVM, UCEC, and PAAD are the cancer types where SPTB RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Quartile	All	0.446	0.863	<.001	53	view →
UCEC	DFS	Tertile	All	0.764	0.866	.003	44	view →
PAAD	DFS	Tertile	All	0.461	0.200	<.001	37	view →
BLCA	OS	Quartile	IV	0.139	0.572	.005	29	view →
ACC	OS	Tertile	II,III,IV	0.877	0.640	.008	26	view →
SKCM	DFS	Tertile	II,III,IV	0.773	0.605	.011	25	view →
LIHC	DFS	Median	II,III,IV	0.481	0.202	.002	25	view →
LUAD	DFS	Median	III,IV	0.739	0.503	.006	19	view →
OV	DFS	Quartile	All	0.618	0.510	.020	16	view →
COAD	DFS	Median	All	0.740	0.832	.014	12	view →
CHOL	OS	Median	All	0.599	0.938	.015	10	view →
READ	DFS	Median	III,IV	0.522	0.857	.010	7	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

SPTB–UVM (DFS)

Open the UVM breakdown →