SPTB

Across TCGA patient cohorts, SPTB mutation is significantly associated with the total protein of many other genes, with 89 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPTB-associated genes across cancer lineages are STAT3_pY705, Lck, and S6_pS240_S244. Each is linked with SPTB in more than 2 cancer types. Because this analysis shows association rather than direction, both SPTB-to-partner and partner-to-SPTB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, STAT3_pY705 grouped by SPTB-low versus SPTB-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPTB→partner) and Y-score (partner→SPTB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	STAT3_pY705 →	-0.434	-1.750	<.001	<.001	3	3
COAD	Lck →	+0.249	+2.273	.014	<.001	3	3
COAD	S6_pS240_S244 →	+0.359	+3.472	.006	.002	3	3
COAD	TSC1 →	-0.245	-1.493	.007	.028	3	3
UCEC	Cyclin-B1 →	+0.611	+1.584	<.001	<.001	3	3
COAD	INPP4B →	-0.335	-3.584	.006	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 89 associations by consensus.

STAT3_pY705 by SPTB expression — UCEC

Explore this box plot interactively →