SPTB

Across TCGA cell cohorts, SPTB RNA expression is significantly associated with the go_rna of many other GO terms, with 4,108 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SPTB-associated GO terms across cancer lineages are Regulation of myoblast fusion, Negative regulation of myoblast fusion, and Negative regulation of syncytium formation by plasma membrane fusion. Each is linked with SPTB in more than 14 cancer types. Because this analysis shows association rather than direction, both SPTB-to-partner and partner-to-SPTB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of myoblast fusion grouped by SPTB-low versus SPTB-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SPTB→partner) and Y-score (partner→SPTB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Regulation of myoblast fusion →	+0.154	+1.016	<.001	.001	3	15
OESOPHAGUS	Negative regulation of myoblast fusion →	+0.135	+0.913	<.001	<.001	3	13
OESOPHAGUS	Negative regulation of syncytium formation by plasma membrane fusion →	+0.136	+1.012	<.001	<.001	3	13
OESOPHAGUS	Regulation of proteasomal protein catabolic process →	+0.081	+0.879	<.001	.001	3	13
OESOPHAGUS	Establishment of protein localization to organelle →	+0.067	+0.964	.001	.005	2	13
OESOPHAGUS	Cytoplasmic translation →	+0.087	+0.745	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,108 associations by consensus.

Regulation of myoblast fusion by SPTB expression — OESOPHAGUS

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