SPTB

Across TCGA cell cohorts, SPTB mutation is significantly associated with the RNA expression of many other genes, with 911 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SPTB-associated genes across cancer lineages are HSD3B2, TTC21B, and PSRC1. Each is linked with SPTB in more than 4 cancer types. Because this analysis shows association rather than direction, both SPTB-to-partner and partner-to-SPTB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HSD3B2 grouped by SPTB-low versus SPTB-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPTB→partner) and Y-score (partner→SPTB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	HSD3B2 →	+0.026	+2.117	<.001	.006	3	5
LARGE_INTESTINE	TTC21B →	+0.453	+2.364	.006	<.001	3	3
LARGE_INTESTINE	PSRC1 →	+0.712	+2.364	<.001	<.001	3	3
LARGE_INTESTINE	SEMA4F →	+0.719	+1.850	.003	.006	3	3
LARGE_INTESTINE	COPS3 →	+0.534	+2.364	.002	<.001	3	3
LARGE_INTESTINE	AURKB →	+0.582	+3.043	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 911 associations by consensus.

HSD3B2 by SPTB expression — BLOOD_Leukemia

Explore this box plot interactively →