SPRYD4

Across TCGA patient cohorts, SPRYD4 mutation is significantly associated with the RNA expression of many other genes, with 51 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPRYD4-associated genes across cancer lineages are MIR6801, RNU6-1211P, and RPS29P26. Each is linked with SPRYD4 in more than 1 cancer types. Because this analysis shows association rather than direction, both SPRYD4-to-partner and partner-to-SPRYD4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR6801 grouped by SPRYD4-low versus SPRYD4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPRYD4→partner) and Y-score (partner→SPRYD4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MIR6801 →	+0.613	+2.958	.002	.005	3	1
SKCM	RNU6-1211P →	+0.283	+7.816	<.001	.008	3	1
SKCM	RPS29P26 →	+0.718	+7.816	<.001	.008	3	1
UCEC	MIR4685 →	+1.014	+4.078	.001	<.001	3	1
COAD	MORF4L1P6 →	+0.277	+7.741	<.001	.009	3	1
UCEC	SSX6P →	+0.292	+4.218	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 51 associations by consensus.

MIR6801 by SPRYD4 expression — UCEC

Explore this box plot interactively →