SPRYD4

Across TCGA pan-cancer cohorts, SPRYD4 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated SPRYD4 data layer compared with 6 for mass-spec protein.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher SPRYD4 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated SPRYD4 expression acts as an unfavorable survival marker, although some lineages such as LUSC and KIRP show a favorable association.

SKCM, UVM, and ACC are the cancer types where SPRYD4 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	OS	Median	All	0.823	0.918	<.001	129	view →
UVM	OS	Tertile	All	0.403	0.928	<.001	104	view →
ACC	DFS	Median	All	0.260	0.660	<.001	88	view →
LUSC	OS	Tertile	All	0.821	0.691	<.001	48	view →
KIRP	OS	Tertile	All	0.937	0.819	.006	39	view →
KIRC	DFS	Tertile	All	0.732	0.570	.001	37	view →
BRCA	OS	Median	IV	0.813	0.325	.002	31	view →
UCEC	DFS	Tertile	All	0.621	0.796	.007	26	view →
LIHC	OS	Quartile	All	0.730	0.514	.005	23	view →
SCLC	DFS	Quartile	All	0.694	0.487	.017	20	view →
STAD	OS	Median	IV	0.642	0.203	.006	18	view →
COAD	DFS	Tertile	III,IV	0.502	0.748	.004	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

SPRYD4–SKCM (OS)

Open the SKCM breakdown →