SPRY1

Across TCGA patient cohorts, SPRY1 RNA expression is significantly associated with the protein abundance of many other proteins, with 18,086 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible SPRY1-associated proteins across cancer lineages are KANK2, PALM2AKAP2, and SEPTIN7. Each is linked with SPRY1 in more than 6 cancer types. Because this analysis shows association rather than direction, both SPRY1-to-partner and partner-to-SPRY1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SPRY1 versus KANK2 in BRCA, with a Pearson correlation of 0.62.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (SPRY1→partner) and Y-score (partner→SPRY1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	KANK2 →	+0.614	+1.282	<.001	<.001	3	7
GBM	PALM2AKAP2 →	+0.467	+1.223	<.001	<.001	3	7
PDAC	SEPTIN7 →	+0.275	+0.459	<.001	<.001	3	6
HNSC	SGCD →	+0.776	+0.478	<.001	<.001	3	6
HNSC	SORBS2 →	+0.582	+0.605	<.001	.002	3	6
BRCA	TGFB1I1 →	+0.487	+1.235	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 18,086 associations by consensus.

SPRY1 vs KANK2 — BRCA

Explore this scatter interactively →