SPRY1

Across TCGA pan-cancer cohorts, SPRY1 RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated SPRY1 data layer compared with 5 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher SPRY1 RNA is associated with better overall survival. In most high-consensus cancer types, elevated SPRY1 expression acts as an unfavorable survival marker, although some lineages such as KIRC and HNSC show a favorable association.

KIRC, KIRP, and LGG are the cancer types where SPRY1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Median	All	0.719	0.544	<.001	101	view →
KIRP	DFS	Median	All	0.862	0.953	<.001	76	view →
LGG	DFS	Median	All	0.631	0.847	<.001	54	view →
HNSC	DFS	Tertile	IV	0.629	0.427	.001	50	view →
SKCM	OS	Median	II,III,IV	0.886	0.786	.002	38	view →
THYM	DFS	Tertile	II,III,IV	0.906	0.421	<.001	31	view →
STAD	DFS	Quartile	All	0.220	0.532	.005	28	view →
LUSC	DFS	Median	All	0.304	0.457	.004	21	view →
OV	DFS	Quartile	IV	0.366	0.649	.009	18	view →
THCA	OS	Median	II,III,IV	0.983	0.908	.004	18	view →
UCS	DFS	Tertile	IV	0.860	0.323	.024	16	view →
UCEC	DFS	Tertile	III,IV	0.879	0.730	.010	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

SPRY1–KIRC (OS)

Open the KIRC breakdown →