SPRTN

Across TCGA patient cohorts, SPRTN mutation is significantly associated with the total protein of many other genes, with 22 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPRTN-associated genes across cancer lineages are p62 Lck ligand, ASNS, and c-Met_pY1235. Each is linked with SPRTN in more than 1 cancer types. Because this analysis shows association rather than direction, both SPRTN-to-partner and partner-to-SPRTN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p62 Lck ligand grouped by SPRTN-low versus SPRTN-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPRTN→partner) and Y-score (partner→SPRTN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p62 Lck ligand →	+0.377	+2.125	.002	.010	3	2
UCEC	ASNS →	+0.413	+2.321	.002	.034	3	2
UCEC	c-Met_pY1235 →	+0.060	+1.710	.034	.025	3	2
UCEC	Cyclin-E2 →	+0.148	+1.678	.022	.023	3	2
UCEC	EGFR_pY1173 →	+0.063	+2.341	.038	.019	3	1
UCEC	FoxM1 →	+0.236	+2.584	.017	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

p62 Lck ligand by SPRTN expression — UCEC

Explore this box plot interactively →