SPRTN

Across TCGA cell cohorts, SPRTN mutation is significantly associated with the RNA expression of many other genes, with 59 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SPRTN-associated genes across cancer lineages are GRIFIN, ASPN, and MRPL19. Each is linked with SPRTN in more than 1 cancer types. Because this analysis shows association rather than direction, both SPRTN-to-partner and partner-to-SPRTN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GRIFIN grouped by SPRTN-low versus SPRTN-high in OESOPHAGUS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPRTN→partner) and Y-score (partner→SPRTN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	GRIFIN →	+0.080	+4.906	<.001	.006	3	1
LARGE_INTESTINE	ASPN →	+0.041	+3.011	<.001	<.001	3	1
LARGE_INTESTINE	MRPL19 →	+0.561	+3.364	.003	.002	3	1
LARGE_INTESTINE	MED21 →	+0.522	+3.234	<.001	.004	3	1
LARGE_INTESTINE	MTHFD2L →	+0.607	+3.364	.004	.002	3	1
LARGE_INTESTINE	POLR1C →	+0.463	+3.364	.002	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 59 associations by consensus.

GRIFIN by SPRTN expression — OESOPHAGUS

Explore this box plot interactively →