SPRR5

Across TCGA patient cohorts, SPRR5 RNA expression is significantly associated with the protein abundance of many other proteins, with 5,309 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible SPRR5-associated proteins across cancer lineages are SPRR2A_S60, SPRR2A, and PKP1_S191. Each is linked with SPRR5 in more than 3 cancer types. Because this analysis shows association rather than direction, both SPRR5-to-partner and partner-to-SPRR5 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SPRR5 versus SPRR2A_S60 in LUAD, with a Pearson correlation of 0.77.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (SPRR5→partner) and Y-score (partner→SPRR5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	SPRR2A_S60 →	+2.612	+0.146	<.001	.009	3	4
UCEC	SPRR2A →	+3.067	+0.194	<.001	.005	3	3
UCEC	PKP1_S191 →	+2.321	+0.138	<.001	.001	3	3
UCEC	PKP1_S237 →	+3.411	+0.161	<.001	.006	3	3
HNSC	MAP7D1_T21 →	+0.506	+1.353	<.001	<.001	3	2
HNSC	SOWAHC →	+0.452	+1.685	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,309 associations by consensus.

SPRR5 vs SPRR2A_S60 — LUAD

Explore this scatter interactively →