SPRR2F

Across TCGA patient cohorts, SPRR2F mutation is significantly associated with the RNA expression of many other genes, with 86 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible SPRR2F-associated genes across cancer lineages are RN7SKP286, RNA5SP247, and GJA1P1. Each is linked with SPRR2F in more than 1 cancer types. Because this analysis shows association rather than direction, both SPRR2F-to-partner and partner-to-SPRR2F results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SKP286 grouped by SPRR2F-low versus SPRR2F-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPRR2F→partner) and Y-score (partner→SPRR2F) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RN7SKP286 →	+0.064	+5.225	<.001	.001	3	2
UCEC	RNA5SP247 →	+0.640	+4.001	.004	.003	3	2
SKCM	GJA1P1 →	+0.096	+3.550	.004	.005	3	1
SKCM	NUDT4B →	+0.067	+2.830	.002	.007	3	1
SKCM	CAV3 →	+0.832	+3.946	<.001	.002	3	1
SKCM	KRTAP19-5 →	+0.628	+3.349	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 86 associations by consensus.

RN7SKP286 by SPRR2F expression — SKCM

Explore this box plot interactively →