SPRR2F

Across TCGA pan-cancer cohorts, SPRR2F RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated SPRR2F data layer compared with 2 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher SPRR2F RNA is associated with worse overall survival. In most high-consensus cancer types, elevated SPRR2F expression acts as an unfavorable survival marker, although some lineages such as LGG and HNSC show a favorable association.

KIRP, KIRC, and SKCM are the cancer types where SPRR2F RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	OS	Tertile	All	0.293	0.735	.001	78	view →
KIRC	DFS	Tertile	All	0.667	0.828	.001	72	view →
SKCM	OS	Tertile	All	0.683	0.821	<.001	61	view →
KICH	DFS	Tertile	All	0.102	0.848	.004	39	view →
PAAD	OS	Median	All	0.303	0.527	.001	31	view →
LGG	OS	Tertile	All	1.000	0.415	.005	21	view →
HNSC	OS	Quartile	III,IV	0.796	0.651	.012	19	view →
GBM	OS	Tertile	All	0.076	0.415	.003	18	view →
THYM	DFS	Tertile	III,IV	0.459	1.000	.010	18	view →
LUSC	DFS	Quartile	II,III,IV	0.565	0.282	.002	17	view →
UCEC	DFS	Median	All	0.803	0.870	.023	16	view →
MESO	DFS	Median	II,III,IV	0.294	0.458	.009	13	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

SPRR2F–KIRP (OS)

Open the KIRP breakdown →