SPRR2A

Across TCGA patient cohorts, SPRR2A mutation is significantly associated with the RNA expression of many other genes, with 72 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible SPRR2A-associated genes across cancer lineages are OR6S1, RNU1-34P, and CYP2A7P1. Each is linked with SPRR2A in more than 1 cancer types. Because this analysis shows association rather than direction, both SPRR2A-to-partner and partner-to-SPRR2A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR6S1 grouped by SPRR2A-low versus SPRR2A-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPRR2A→partner) and Y-score (partner→SPRR2A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	OR6S1 →	+0.089	+3.243	<.001	.009	3	1
SKCM	RNU1-34P →	+0.139	+5.485	<.001	.001	3	1
SKCM	CYP2A7P1 →	+0.029	+4.199	<.001	.009	3	1
SKCM	OR2G1P →	+0.041	+4.097	.003	.002	3	1
SKCM	ASS1P6 →	+0.018	+4.328	<.001	.007	3	1
SKCM	MIR1245A →	+0.509	+3.490	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 72 associations by consensus.

OR6S1 by SPRR2A expression — SKCM

Explore this box plot interactively →