SPRR2A

Across TCGA pan-cancer cohorts, SPRR2A RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of SPRR2A’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where SPRR2A RNA is repressed in tumor relative to normal tissue. In most cancer types SPRR2A is over-expressed in tumor, although a few such as KIRC and KICH show the opposite, repressed pattern.

KIRC, KICH, and COAD are the cancer types where SPRR2A tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SPRR2A RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	III,IV	−0.734	<.001	12	view →
KICH	All	II,III,IV	−0.840	<.001	10	view →
COAD	Female	II,III,IV	+1.141	<.001	8	view →
LUSC	Female	All	+5.821	<.001	7	view →
BLCA	Male	All	+2.321	.043	2	view →
UCEC	All	All	+1.118	.003	2	view →
READ	All	All	+0.877	.028	2	view →
BRCA	All	III,IV	−0.491	.028	2	view →
KIRP	Male	II,III,IV	−0.407	.007	2	view →
THCA	Male	All	+0.062	.029	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

SPRR2A–KIRC

Open the KIRC breakdown →