SPRING1

Across TCGA cell cohorts, SPRING1 mutation is significantly associated with the RNA expression of many other genes, with 16 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SPRING1-associated genes across cancer lineages are MYF6, FTHL17, and TSHB. Each is linked with SPRING1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SPRING1-to-partner and partner-to-SPRING1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MYF6 grouped by SPRING1-low versus SPRING1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPRING1→partner) and Y-score (partner→SPRING1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MYF6 →	+0.009	+4.415	<.001	.007	3	1
LARGE_INTESTINE	FTHL17 →	+0.063	+4.415	<.001	.007	3	1
LARGE_INTESTINE	TSHB →	+0.047	+4.415	<.001	.007	3	1
LARGE_INTESTINE	MCHR2 →	+0.022	+4.684	<.001	.002	3	1
LARGE_INTESTINE	SPRR2G →	+0.655	+4.095	.004	.009	3	1
LARGE_INTESTINE	KCNG4 →	+0.004	+4.415	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

MYF6 by SPRING1 expression — LARGE_INTESTINE

Explore this box plot interactively →