SPRING1

Across TCGA pan-cancer cohorts, SPRING1 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated SPRING1 data layer compared with 3 for mutation status.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where higher SPRING1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated SPRING1 expression acts as an unfavorable survival marker, although some lineages such as KIRC and HNSC show a favorable association.

LIHC, KIRC, and LUSC are the cancer types where SPRING1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LIHC	OS	Median	All	0.609	0.755	<.001	100	view →
KIRC	OS	Median	All	0.732	0.524	<.001	98	view →
LUSC	OS	Median	II,III,IV	0.294	0.552	.002	58	view →
BRCA	OS	Median	II,III,IV	0.473	0.683	.001	42	view →
HNSC	DFS	Tertile	All	0.782	0.618	.001	41	view →
MESO	OS	Median	All	0.196	0.371	.006	38	view →
OV	OS	Median	All	0.809	0.870	.018	30	view →
UCS	OS	Tertile	II,III,IV	0.701	0.275	.003	28	view →
ACC	DFS	Tertile	All	0.516	0.834	.002	26	view →
ESCA	DFS	Median	IV	0.205	0.634	.006	24	view →
KIRP	DFS	Median	All	0.951	0.868	.010	22	view →
CHOL	OS	Median	III,IV	0.286	1.000	.008	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

SPRING1–LIHC (OS)

Open the LIHC breakdown →