Across TCGA patient cohorts, SPRED3 mutation is significantly associated with the RNA expression of many other genes, with 66 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible SPRED3-associated genes across cancer lineages are RNU6-1313P, HMGN1P28, and RNU1-148P. Each is linked with SPRED3 in more than 1 cancer types. Because this analysis shows association rather than direction, both SPRED3-to-partner and partner-to-SPRED3 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPRED3→partner) and Y-score (partner→SPRED3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RNU6-1313P →	+0.593	+7.741	<.001	.009	3	2
UCEC	HMGN1P28 →	+0.323	+3.873	.007	.002	3	2
SKCM	RNU1-148P →	+0.149	+4.385	<.001	.008	3	2
SKCM	MTHFD2P5 →	+0.078	+4.075	<.001	.004	3	2
SKCM	LATS2-AS1 →	+0.141	+4.711	<.001	.001	3	1
SKCM	RAC1P7 →	+0.098	+5.039	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 66 associations by consensus.

Exploration

SPRED3 survival (RNA) · tumor vs normal (RNA) · all SPRED3 data types