Across TCGA pan-cancer cohorts, SPRED3 RNA differs between tumor and matched normal tissue in 16 of 18 cancer types tested, making tumor–normal expression one of SPRED3’s most consistent transcriptional readouts.
The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where SPRED3 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types SPRED3 is over-expressed in tumor, although a few such as KICH show the opposite, repressed pattern.
HNSC, COAD, and THCA are the cancer types where SPRED3 tumor–normal differential expression is most reproducible.
RNA tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SPRED3 RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.