SPRED1

Across TCGA patient cohorts, SPRED1 mutation is significantly associated with the RNA expression of many other genes, with 3,813 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPRED1-associated genes across cancer lineages are FTH1P9, MRPL15P1, and SLC6A14P2. Each is linked with SPRED1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SPRED1-to-partner and partner-to-SPRED1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FTH1P9 grouped by SPRED1-low versus SPRED1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPRED1→partner) and Y-score (partner→SPRED1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	FTH1P9 →	+0.051	+5.643	<.001	<.001	3	2
SKCM	MRPL15P1 →	+0.144	+2.789	<.001	.008	3	2
CESC	SLC6A14P2 →	+0.060	+4.252	<.001	.006	3	2
CESC	RN7SL248P →	+0.059	+5.000	<.001	.001	3	2
BRCA	RNU6-23P →	+0.389	+5.160	<.001	<.001	3	2
UCEC	RNA5SP412 →	+0.429	+1.645	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,813 associations by consensus.

FTH1P9 by SPRED1 expression — SKCM

Explore this box plot interactively →