SPPL2A

Across TCGA patient cohorts, SPPL2A mutation is significantly associated with the RNA expression of many other genes, with 995 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPPL2A-associated genes across cancer lineages are RNU6-163P, PRRX2-AS1, and SUCLA2P2. Each is linked with SPPL2A in more than 1 cancer types. Because this analysis shows association rather than direction, both SPPL2A-to-partner and partner-to-SPPL2A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-163P grouped by SPPL2A-low versus SPPL2A-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPPL2A→partner) and Y-score (partner→SPPL2A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RNU6-163P →	+0.260	+4.537	<.001	.006	3	2
COAD	PRRX2-AS1 →	+0.239	+3.646	<.001	.009	3	2
LUAD	SUCLA2P2 →	+0.043	+4.279	.001	.001	3	2
LUAD	TUBB8P5 →	+0.093	+3.760	.002	.003	3	2
LGG	RNU6-1315P →	+0.379	+4.987	.002	.009	3	2
SKCM	OR7E148P →	+0.044	+4.470	.006	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 995 associations by consensus.

RNU6-163P by SPPL2A expression — COAD

Explore this box plot interactively →