SPP1

Across TCGA cell cohorts, SPP1 mutation is significantly associated with the mutation status of many other genes, with 1,175 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SPP1-associated genes across cancer lineages are COL4A4, CCDC180, and HAUS3. Each is linked with SPP1 in more than 2 cancer types. Because this analysis shows association rather than direction, both SPP1-to-partner and partner-to-SPP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, COL4A4 grouped by SPP1-low versus SPP1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPP1→partner) and Y-score (partner→SPP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	COL4A4 →	+2.825	+3.847	.001	.001	1	3
LUNG_NSCLC_LUAD	CCDC180 →	+3.000	+3.662	.007	.007	1	3
LUNG_NSCLC_LUAD	HAUS3 →	+5.000	+4.187	.008	.008	1	3
LUNG_NSCLC_LUAD	REG1A →	+3.000	+3.662	.007	.007	1	3
LARGE_INTESTINE	SCN4A →	+1.836	+2.906	.009	.009	1	3
BLOOD_Leukemia	PARD3B →	+3.063	+3.498	.006	.006	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,175 associations by consensus.

COL4A4 by SPP1 expression — BLOOD_Leukemia

Explore this box plot interactively →