HAUS augmin like complex subunit 3Genealiases: C4orf15 · IT1 · dgt3
Q-omics provides the consensus-scored HAUS3 profile across patient tissues and cancer cell-line models. HAUS3 expression is associated with patient survival in 30 of 34 cancer types, with the highest sampling consensus in UCS. Among the 18 cancer types available for tumor–normal comparison, HAUS3 is differentially expressed in 13, with the highest sampling consensus in HNSC. Additionally, HAUS3 protein abundance shows 21,511 significant protein co-abundance associations, with the highest sampling consensus in LUAD. Together, these results highlight UCS, HNSC, and LUAD as cancer lineages where HAUS3 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for HAUS3 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes HAUS3 survival associations across molecular data types. HAUS3 RNA expression shows survival associations in the most cancer types (30), followed by mutation status (3) and mass-spec protein abundance (7). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible HAUS3 RNA expression–survival associations across cancer types. High HAUS3 expression shows unfavorable associations in UVM, LGG, LIHC and KICH, but favorable associations in UCS and SKCM. The UCS Kaplan–Meier curve shows clear separation, with the low-expression group declining faster, consistent with the favorable association (log-rank p = .001). Together, the overview and detailed table identify UCS as the clearest survival context for HAUS3 RNA expression.
This table summarizes HAUS3 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 13, while mass-spec protein shows differences in 5. The strongest signals are observed in HNSC for RNA and CCRCC for protein.
This table ranks reproducible tumor–normal expression differences for HAUS3. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. HAUS3 shows lower tumor expression in THCA and higher tumor expression in HNSC, KIRC, LIHC, BLCA and CHOL. The HNSC box plot shows higher HAUS3 RNA expression in tumor versus normal tissue (log2 FC = +0.555, t-test p < 0.001).
This table shows molecular features associated with HAUS3 in patient tissues and cancer cell lines. In patient samples, HAUS3 shows the broadest associations at the RNA and protein expression levels, with LUAD recurring as the lineage with the largest associated feature set. In cancer cell lines, HAUS3 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in CNS, while CRISPR and shRNA rows add functional-dependency signals in URINARY_TRACT and BLOOD_Leukemia.
