SPP1

Across TCGA pan-cancer cohorts, SPP1 RNA differs between tumor and matched normal tissue in 18 of 18 cancer types tested, making tumor–normal expression one of SPP1’s most consistent transcriptional readouts.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where SPP1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types SPP1 is over-expressed in tumor, although a few such as KICH and PAAD show the opposite, repressed pattern.

BLCA, HNSC, and COAD are the cancer types where SPP1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SPP1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BLCA	Female	III,IV	+6.101	<.001	12	view →
HNSC	Male	III,IV	+4.029	<.001	12	view →
COAD	Male	IV	+5.462	<.001	11	view →
LUAD	Male	III,IV	+5.695	<.001	9	view →
LUSC	Male	III,IV	+4.949	<.001	8	view →
THCA	All	III,IV	+2.081	<.001	8	view →
LIHC	Male	II,III,IV	+4.525	<.001	7	view →
UCEC	All	III,IV	+4.981	<.001	6	view →
STAD	Male	II,III,IV	+3.782	<.001	6	view →
BRCA	All	III,IV	+2.640	<.001	6	view →
KIRP	Male	II,III,IV	+1.927	<.001	6	view →
READ	All	II,III,IV	+4.389	.009	5	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 18 lineages.

SPP1–BLCA

Open the BLCA breakdown →