SPO11

Across TCGA patient cohorts, SPO11 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,986 significant associations in total. STAD shows the largest number of these associations.

The most reproducible SPO11-associated GO terms across cancer lineages are Regulation of DNA repair, Cellular respiration, and Mitotic recombination. Each is linked with SPO11 in more than 10 cancer types. Because this analysis shows association rather than direction, both SPO11-to-partner and partner-to-SPO11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of DNA repair grouped by SPO11-low versus SPO11-high in STAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SPO11→partner) and Y-score (partner→SPO11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	Regulation of DNA repair →	+0.060	+0.062	<.001	<.001	3	11
STAD	Cellular respiration →	+0.070	+0.070	<.001	<.001	3	11
STAD	Mitotic recombination →	+0.049	+0.061	<.001	<.001	3	10
STAD	tRNA metabolic process →	+0.064	+0.061	<.001	<.001	3	10
STAD	RNA modification →	+0.058	+0.057	<.001	<.001	3	10
STAD	rRNA metabolic process →	+0.069	+0.068	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,986 associations by consensus.

Regulation of DNA repair by SPO11 expression — STAD

Explore this box plot interactively →