SPO11

Across TCGA pan-cancer cohorts, SPO11 RNA is linked to patient survival in 14 of 34 cancer types, making it the most broadly survival-associated SPO11 data layer compared with 6 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher SPO11 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated SPO11 expression acts as an unfavorable survival marker, although some lineages such as STAD and HNSC show a favorable association.

COAD, KIRC, and STAD are the cancer types where SPO11 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	OS	Tertile	IV	0.150	0.666	<.001	147	view →
KIRC	DFS	Tertile	All	0.390	0.665	.001	66	view →
STAD	OS	Tertile	III,IV	0.786	0.363	.004	63	view →
UVM	OS	Tertile	All	0.220	0.917	<.001	54	view →
HNSC	OS	Tertile	IV	0.591	0.330	.015	39	view →
OV	DFS	Tertile	II,III,IV	0.211	0.140	.012	36	view →
LAML	DFS	Tertile	All	0.183	0.421	.007	36	view →
KIRP	DFS	Tertile	All	0.243	0.629	.005	33	view →
LUAD	DFS	Tertile	IV	0.047	0.565	<.001	18	view →
THCA	DFS	Tertile	All	0.982	0.816	.026	12	view →
GBM	OS	Tertile	All	0.677	0.378	.020	9	view →
ESCA	OS	Tertile	II,III,IV	0.403	0.902	.024	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 14 lineages.

SPO11–COAD (OS)

Open the COAD breakdown →