SPO11

Across TCGA pan-cancer cohorts, SPO11 RNA differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of SPO11’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where SPO11 RNA is repressed in tumor relative to normal tissue. In most cancer types SPO11 is over-expressed in tumor, although a few such as THCA show the opposite, repressed pattern.

THCA, BRCA, and LUAD are the cancer types where SPO11 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SPO11 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	III,IV	−0.084	<.001	11	view →
BRCA	All	All	+0.008	.011	2	view →
LUAD	All	All	+0.008	.030	1	view →
LUSC	All	All	+0.007	.049	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

SPO11–THCA

Open the THCA breakdown →