SPO11

Across TCGA patient cohorts, SPO11 protein abundance is significantly associated with the RNA expression of many other genes, with 6,456 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible SPO11-associated genes across cancer lineages are GGTLC2, CCDC198, and GINS1. Each is linked with SPO11 in more than 1 cancer types. Because this analysis shows association rather than direction, both SPO11-to-partner and partner-to-SPO11 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SPO11 versus GGTLC2 in LUAD, with a Pearson correlation of -0.45.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPO11→partner) and Y-score (partner→SPO11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	GGTLC2 →	-0.695	-1.376	.002	.002	3	1
LUAD	CCDC198 →	-0.852	-1.120	.006	.007	3	1
LUAD	GINS1 →	+1.220	+1.193	.004	.008	3	1
LUAD	CDC25B →	+1.166	+1.600	.001	<.001	3	1
LUAD	MXRA5 →	+1.737	+1.842	<.001	<.001	3	1
LUAD	ABCD1 →	+0.683	+1.463	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,456 associations by consensus.

SPO11 vs GGTLC2 — LUAD

Explore this scatter interactively →