SPO11

Across TCGA patient cohorts, SPO11 mutation is significantly associated with the RNA expression of many other genes, with 2,529 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPO11-associated genes across cancer lineages are RNU6-419P, SNORD62A, and RNF103-CHMP3. Each is linked with SPO11 in more than 2 cancer types. Because this analysis shows association rather than direction, both SPO11-to-partner and partner-to-SPO11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-419P grouped by SPO11-low versus SPO11-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPO11→partner) and Y-score (partner→SPO11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNU6-419P →	+0.389	+1.851	<.001	.004	3	3
SKCM	SNORD62A →	+0.539	+2.520	.001	.007	3	2
SKCM	RNF103-CHMP3 →	+0.169	+3.529	<.001	.002	3	2
UCEC	BAG3 →	+0.711	+4.064	<.001	<.001	3	2
UCEC	GPATCH11 →	+0.513	+3.130	<.001	<.001	3	2
SKCM	CWC27 →	+0.685	+3.491	.006	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,529 associations by consensus.

RNU6-419P by SPO11 expression — UCEC

Explore this box plot interactively →