SPO11

Across TCGA patient cohorts, SPO11 mutation is significantly associated with the total protein of many other genes, with 34 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPO11-associated genes across cancer lineages are MEK1, Notch1, and ATM. Each is linked with SPO11 in more than 1 cancer types. Because this analysis shows association rather than direction, both SPO11-to-partner and partner-to-SPO11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by SPO11-low versus SPO11-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPO11→partner) and Y-score (partner→SPO11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.490	+3.087	<.001	<.001	3	2
UCEC	Notch1 →	+0.212	+2.736	<.001	<.001	3	2
UCEC	ATM →	-0.401	-1.502	.016	.030	3	2
UCEC	4E-BP1 →	+0.354	+3.489	<.001	.002	3	2
UCEC	EGFR_pY1068 →	-0.259	-2.584	.004	.010	3	1
UCEC	eIF4E →	+0.195	+3.335	.011	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 34 associations by consensus.

MEK1 by SPO11 expression — UCEC

Explore this box plot interactively →