SPO11

Across TCGA cell cohorts, SPO11 RNA expression is significantly associated with the mutation status of many other genes, with 99 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SPO11-associated genes across cancer lineages are MYOM1, CASP14, and MT-ND1. Each is linked with SPO11 in more than 2 cancer types. Because this analysis shows association rather than direction, both SPO11-to-partner and partner-to-SPO11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MYOM1 grouped by SPO11-low versus SPO11-high in LUNG_NSCLC_LUAD.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPO11→partner) and Y-score (partner→SPO11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	MYOM1 →	+3.362	+0.051	.007	<.001	3	3
CNS	CASP14 →	+5.357	+0.017	.001	<.001	3	2
BREAST	MT-ND1 →	+2.727	+0.020	.001	<.001	3	2
BLOOD_Leukemia	PMFBP1 →	+4.969	+0.017	.003	<.001	3	2
BLOOD_Leukemia	AKAP12 →	+3.969	+0.013	.009	<.001	3	2
BLOOD_Leukemia	UBR3 →	+5.969	+0.022	.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 99 associations by consensus.

MYOM1 by SPO11 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →