SPO11

Across TCGA cell cohorts, SPO11 mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible SPO11-associated genes across cancer lineages are C6orf118, RNASE9, and OR8B4. Each is linked with SPO11 in more than 1 cancer types. Because this analysis shows association rather than direction, both SPO11-to-partner and partner-to-SPO11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C6orf118 grouped by SPO11-low versus SPO11-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPO11→partner) and Y-score (partner→SPO11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	C6orf118 →	+0.175	+3.793	<.001	.007	3	1
LUNG_NSCLC_LUAD	RNASE9 →	+0.011	+4.887	.009	.009	3	1
LUNG_NSCLC_LUAD	OR8B4 →	+0.027	+4.887	<.001	.009	3	1
SKIN	SPATA48 →	+0.012	+4.977	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

C6orf118 by SPO11 expression — LARGE_INTESTINE

Explore this box plot interactively →