SPINK4

Across TCGA patient cohorts, SPINK4 protein abundance is significantly associated with the RNA expression of many other genes, with 3,816 significant associations in total. COAD shows the largest number of these associations.

The most reproducible SPINK4-associated genes across cancer lineages are CLDN20, RBM38-AS1, and ASS1P3. Each is linked with SPINK4 in more than 1 cancer types. Because this analysis shows association rather than direction, both SPINK4-to-partner and partner-to-SPINK4 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SPINK4 versus CLDN20 in COAD, with a Pearson correlation of -0.32.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPINK4→partner) and Y-score (partner→SPINK4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	CLDN20 →	-0.418	-0.919	.002	<.001	3	2
COAD	RBM38-AS1 →	-0.364	-0.739	<.001	.001	3	2
COAD	ASS1P3 →	+0.230	+0.801	.003	.004	3	2
COAD	DUSP14 →	-0.387	-0.829	.003	.004	3	2
COAD	TOP3B →	-0.042	-0.816	.004	<.001	3	1
COAD	LGALS2 →	+1.076	+0.987	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,816 associations by consensus.

SPINK4 vs CLDN20 — COAD

Explore this scatter interactively →