Q-omics provides the consensus-scored ASS1P3 profile across patient tissues and cancer cell-line models. ASS1P3 expression is associated with patient survival in 21 of 34 cancer types, with the highest sampling consensus in UVM. Among the 18 cancer types available for tumor–normal comparison, ASS1P3 is differentially expressed in 10, with the highest sampling consensus in KIRP. Additionally, ASS1P3 RNA expression shows 10,322 significant gene co-expression associations, with the highest sampling consensus in ESCA. Together, these results highlight UVM, KIRP, and ESCA as cancer lineages where ASS1P3 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for ASS1P3 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes ASS1P3 survival associations across molecular data types. ASS1P3 RNA expression shows survival associations in the most cancer types (21). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible ASS1P3 RNA expression–survival associations across cancer types. High ASS1P3 expression shows unfavorable associations in UVM, KICH and CHOL, but favorable associations in COAD, SKCM and KIRP. The UVM Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p = .011). Together, the overview and detailed table identify UVM as the clearest survival context for ASS1P3 RNA expression.
This table summarizes ASS1P3 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 10. The strongest signals are observed in KIRP for RNA.
This table ranks reproducible tumor–normal expression differences for ASS1P3. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. ASS1P3 shows lower tumor expression in KIRP, KIRC, BRCA and KICH and higher tumor expression in COAD and STAD. The KIRP box plot shows higher ASS1P3 RNA expression in normal versus tumor tissue (log2 FC = −0.504, t-test p < 0.001).
This table shows molecular features associated with ASS1P3 in patient tissues and cancer cell lines. In patient samples, ASS1P3 shows the broadest associations at the RNA and protein expression levels, with ESCA recurring as the lineage with the largest associated feature set.
