SPIN1

Across TCGA patient cohorts, SPIN1 mutation is significantly associated with the RNA expression of many other genes, with 3,503 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPIN1-associated genes across cancer lineages are RNA5SP534, USP9YP10, and RNU6-1084P. Each is linked with SPIN1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SPIN1-to-partner and partner-to-SPIN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP534 grouped by SPIN1-low versus SPIN1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPIN1→partner) and Y-score (partner→SPIN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNA5SP534 →	+0.195	+2.171	.002	.006	3	2
LGG	USP9YP10 →	+0.049	+7.977	<.001	.007	3	2
UCEC	RNU6-1084P →	+0.122	+4.122	<.001	<.001	3	2
UCEC	RN7SKP214 →	+0.238	+2.112	<.001	<.001	3	2
UCEC	TRAJ1 →	+0.361	+1.770	.002	.005	3	2
COAD	RNU6-1145P →	+0.724	+5.557	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,503 associations by consensus.

RNA5SP534 by SPIN1 expression — UCEC

Explore this box plot interactively →